- There is an edited version for basic cable and broadcast television which appeared on the WE channel (and probably other outlets) after September 11, 2001, where several shots of the World Trade Center have been expunged (along with the usual swear words, drug references, etc.)
- Desperately Seeking Susan was intended as an R-rated movie. To address Madonna's very young fanbase, the movie was trimmed to meet PG-13 criteria. It never received an uncut release.
- The song heard in the movie's beginning is "The Shoop Shoop Song (It's in His Kiss)" in the US version whereas it is "One Fine Day" in the European version, possibly for copyright reasons.
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