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- A magician's heart stops during a performance. At first House dismisses the case, but later changes his mind when complications arise. House has a contest to determine the next one to leave the team.
- A woman collapses at her wedding. She led a different life style before her marriage, House insists she hasn't changed. Wilson starts dating Amber.
- A bus that House was riding crashes. House claims there's a victim on the bus who is dying, but not from the bus accident. He stops at nothing to figure out who the patient is and what is ailing him/her.
- The team works to save someone close to a central character's heart. The key is inside House's head, but he is in a bad way himself.
- The drug trial brings back memories for Thirteen; Kutner and Taub scramble as they try to salvage a scam and save the team's patient whose gastric bypass may not have saved her life.
- A teenager collapses on stage, and the outcome will lead to a surprise for Cuddy. Wilson convinces House to be nice to his patients during the holidays. Foreman and Thirteen have issues when a trial patient drops from the program.
- House treats a priest who's lost his faith, issues an ultimatum to Foreman and Thirteen, and plays with Cuddy's desire to have him attend - or is it not attend? - her baby's naming ceremony.
- House's team resents being made complicit in a web of lies parents have told their son when he's brought in for treatment that may be related to his intersexuality. Meanwhile, no one's content that House is happy.
- The team tries to diagnose a condition that leaves the patient saying anything that he thinks, no matter whom it hurts, and Wilson raises House's antennae when he passes up a monster truck rally.
- House treats a patient who is convinced she's dying because of a death predicting cat. Meanwhile Taub catches up with an old High School classmate and contemplates leaving the team.
- Years after receiving body parts from an organ donor, five out of six recipients die within a few months, but not from organ rejection. House and the team race against time to figure out why before the final surviving recipient, a young woman who received the donor's cornea, mysteriously dies as well. House retains a comical private investigator to investigate patients, doctors, and his estranged friend, Wilson.
- Taub treats a patient whose dying husband gets better as she becomes sicker, while the rest of the team deals with a devastating loss.
- House's Amber hallucination becomes more aggressive as sleep deprivation takes its toll endangering a patient, and Chase's bachelor party ends in the emergency room.
- House's investigator gets information on everyone, which House uses to stir the pot of their lives while the team tries to cure a portraitist whose artistic view now looks like Picasso.
- House tries every delaying tactic available when Wilson forces him to attend his father's funeral. Meanwhile, the team tries to find the cause of a young woman's abdominal pain and hemorrhage that occurred in China.
- Thirteen's one night stand collapses at her apartment, and her symptoms are so misleading that the diagnosis may be terminal. Meanwhile, revelation about Wilson and Thirteen occupy House.
- The team tries to treat a patient who keeps lying to them, and Foreman exerts some independence.