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- A victim of illegal plastic surgery, a woman who is allergic to everything, a rare medical condition that causes hair-raising symptoms, and a real life "popeye" are all considered Taboo.
- One woman who has created a business around her massive size, a couple that that proves relationships are a matter of give and take, a woman whose fears push her into heavy territory, and club-goers that defy the rules of the velvet rope, are all people who challenge the American ideals of health and beauty.
- A doctor who takes his patients to new heights, a man with a poisonous passion for self-immunization, a priest who turns to the dark arts for spiritual illumination, and a man who treats diseases with blood sucking organisms, are all people who embrace extreme medicine.