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1-50 of 88
- The cases of rugged young Dr. Locke and his crusty mentor Dr. Sellers.
- Josie, daughter of prominent banker Sam Macklin, is found beaten and accusations flow as to who is responsible. Town tough Ned is jailed but further investigation by Dr. Locke reveal a young man Henny is suffering from severe headaches and blackouts. After Henny disappears, Ned's help is needed.
- Frank is a veteran beat cop who Dr. Locke discovers is slowly being poisoned after he collapses. The two team up to discover who is behind the attempt and why. The return of a drug kingpin may provide the answer.
- A lunatic is calling in false medical emergencies and killing the paramedics that respond. After losing his last partner, Dr. Locke is assigned Andrea, a colleague he formerly dated. Simon becomes overprotective but she insists she can do the job. The killer shows no partiality.
- Insurance agent Ben Grover stumbles onto a lucrative scam his bosses are using to steal from the company. Before he acts on it, an assassin is used to take him out, but they manage to only kill his wife instead. Grover then turns the tables seeking a deadly revenge.
- Charley is part of a loan shark operation but hasn't been turning in his client's payments. When several of them are severely beaten Dr. Locke is called in and he starts to add things up. Charley's daughter Ruth and her expensive tastes may be the problem.
- Detective Richard Gar is accused of being a dirty cop in a mobster's memoir. He declares his innocence to Dr. Locke who believes him. But his actions to clear his name go too far.
- Tom Fairly holds a compensation board captive after they decide his father's life was worth only fifty dollars. Dr. Locke becomes part of the situation when he arrives to treat a hostage, putting his own life at risk.
- Lt. Dan helicopters Dr. Locke to the home of Helen and Dave because the husband starts having a heart attack during a quarrel. In the air Dan learns a dangerous criminal has escaped and is later wounded by the convict. Dr. Locke is determined to save the husband and his friend while Dan is resolute that a killer must be recaptured.
- Bill, a former resident of Dixion Mills, comes back to town after receiving a terminal diagnosis. Dr. Locke is concerned about his actions and is adamant he deal with reality. The sheriff must locate an older man with a rifle who has been angered by his abusive business partner.
- While transporting a prisoner Dr. Simon Locke is poisoned Lt. Palmer is desperate to learn the type to provide an antidote. He focuses on criminal Duncan but when he's shot Palmer must look to someone he's close to.
- Bill Grady is a exceptional hockey player but drugs and a gambling syndicate have their hold on him. Dr. Locke discovers his hidden addiction and after convincing a protective brother Ed of the situation, they take drastic action.
- A mental block afflicts a museum guard who was the sole witness to a murder.
- Dr. Simon Locke is called to treat a severely beaten woman. Persistent questioning by the physician reveals that Phyllis and Delbert are siblings who run a badger scheme. Their current target is a local politician who doesn't take kindly to being blackmailed.
- Ed Morgan runs a construction business and has several near fatal "accidents". Dr. Locke patches him up but is determined to get to the source of the problem. Ed wants out of a syndicate smuggling opration but they consider him essential.
- Police Officer Mac Houston is traumatized when his partner is murdered and Dr. Locke is assigned to observe him to see if he's fit for active duty. While on patrol they encounter the killer and Locke gets his answer.
- After a party, a millionaire's mansion is invaded and his prize painting is stolen, and a guard is wounded. His neglected wife turns out to have organized it as a prank, but it has spiraled out of control when the thief is determined to collect ransom.
- Lt. Dan Palmer enlists Dr. Locke's help in exposing a nightclub that is a front for a lucrative drug trade. The doctor is also intrigued by an attractive singer at the bar.
- A politician witnesses a mob murder but lets his mistress Nora tell the police she saw it. Dr. Locke becomes involved after he says she has a medical condition to make that impossible but a hitman still goes after her.
- Dr. Simon Locke treats an extortionist Paul Shaver after he is shot. When he once again evades conviction, Simon works to have him brought to justice. Shaver's girlfriend Arline may provide the crucial information.
- A stolen cache of heroin puts Dr. Simon Locke on the trail of a missing police sergeant.
- James Blinn's attempt to rob a record store goes awry when the proprietor suffers a heart attack. He takes a customer hostage along with Dr. Locke who enters the store to give medical attention.
- Policewoman Molly Sims increasingly cuts corners, including giving suspects the benefit of the doubt. Dr.Locke tries to convince her that it won't end well and Lenny, a hoodlum, intends to make her regret the break she gave him.
- Dr. Sellers runs into Ellen Hewitt, an old flame, in the city and she accompanies him back to Dixion Mills. But after she had a medical examine with Dr. Locke, he has unfortunate news to deliver.
- After a bitter custody dispute, Jeff, a mute boy, is placed in his father Burt's care instead of his mother Stella. He climbs the town water tower in the middle of winter in protest, drawing Dr. Sellers and Dr. Locke into the situation.
- Dr. Sellers and Dr. Locke decide to prepare a patient for delicate heart surgery after some debate. But their task is interrupted when two bank robbers take them hostage.
- Dr. Locke gives up a successful practice in the city to join Dr. Sellers in rural Canada. They clash over different styles particularly over one of their first cases involving alcohol poisoning.
- Dr. Simon Locke is sent too look in on a young couple living away from civilization and the woman is close to giving birth. Complications occur and Simon must convince the father that modern science can save his baby.
- Dr. Sellers suffers from a brain malady and Dr. Locke calls in his friend Max, a brilliant neurosurgeon, for assistance. But Max is undergoing a crisis of confidence and refuses to operate.
- Jeff and Lenny are the sons of a hard luck criminal and when Lenny continues getting sicker, Jeff decides to call for medical help. Dr. Locke determines Lenny needs a kidney transplant and his father, hiding out after a botched bank robbery, may be the only one who can save his life.
- Jean, a veteran policewoman, manages to escape from a rapist/murderer. She is ordered to take medical leave but Dr. Locke refuses to sign off, believing it's better for her to return to duty. Jean becomes focused on finding the man before he strikes again.
- Crime figure Tabor is in custody so his henchman kidnap prosecutor Paul Madden in front of his wife. Exton contacts Lt. Gordon and Locke to exchange the two but they decline. A wounded Madden needs rescuing before he dies.
- After a bulldozer errantly knocks down a wall at a demo project, the father of the demolition team is rushed to the hospital while his son, Niko (Chakiris), finds $200,000 in the debris. After some debate, Niko agrees to turn the money over to police. The only trouble is the money is from a nearby robbery, in which $300,000 was stolen. The culprits want the missing loot.
- A series of bombings occur with the description of an old grey haired woman nearby. After questioning unlikely matrons Palmer and Locke dig deeper, learning of Jerry, a lonely man who holds grudges and is good at disguises.
- A second rate lounge singer playing second rate lounges wants desperately for his agent to book him in more important venues in the United States, but he never gets one. When the agent is found murdered in his dressing room, it looks like his spaced out drug addict girl friend did it, but she can't remember anything.
- In a remote farmhouse, a woman tends for her chronically ill, bedridden husband. Though Sellers sees the man living many more years with proper care, he dies very soon afterward. Locke performs an autopsy, and it's revealed his oxygen tank was replaced by inert gas.
- Locke is slightly hurt after a dynamite bomb goes off in the front yard of Dr. Sellers. Soon after, Sellers is occupied by a long time girl patient that seemingly goes crazy during an examination, and her father has a raging mistrust of him because of his age, blaming him for her condition.
- An unconscious man is found in one of the rides at an itinerant fun fair, and Locke diagnoses him as suffering from Typhus. Swiftly, the town of Dixon Mills is quarantined, leading to hardships for the angry and frightened residents. The disease's carrier has fled, and a desperate search ensues.
- A young Indian girl is pregnant, and soon to have her baby, however her husband wants to have it in hospital, but she would prefer the care of her tribe's medicine man, with his magic spells. Locke is bitten by a snake, with only the old shaman to help.
- The town is in an uproar over the Quarantine, and police are still on the trail of a fugitive believed to be the Typhus carrier, but it's revealed he's running from a petty crime warrant. After Palmer becomes ill, he is shocked to find that the real carrier is the girl he's fallen in love with.
- At a surprise fortieth birthday party for a local farmer, he starts punching out his friends, and later tells his wife he detests her because she's aging. It looks like a serious case of midlife crisis, but Locke determines he's affected by agricultural chemicals.
- On a dangerous mountain road deep in the woods, a distracted minister in a passenger car and a volatile chemical truck driven by a man arguing with his daughter, collide. Locke, Sellers and Palmer are soon on the wreck scene and find the trucker pinned inside as the truck may explode. The land's owner complicates things as he tries to stop their help.
- During hunting season,some of the deer hunters are being hunted down themselves, by a demented man with a tranquilizer dart gun. He ties the unconscious men to car hoods like deer carcasses. when Officer Palmer tries to set a trap, but it backfires and Locke takes action.
- One of Doctor Locke's old patients back in the big city insists-even at the cost of his own health, that Locke and only Locke can do his diagnosis. So he leaves Dixon Mills to do it. Everyone worries he may decide to stay, while Sellers alone treats a mysteriously ill family at his surgery.
- Dr. Locke and Dr. Sellers involve themselves in the difficulties of the Kinmonds. Ralphey has a mental condition but still notices his dad Henry treats him different than his siblings. His mother Marge has had enough of her husband's behavior.
- A girl with a degenerative disease walks with great pain trying to conceal her problem from an itinerant French ski bum she's fallen for. Sellers insists she must let him go or risk irreparable damage to her legs, and delay will prevent her admission to college as well.
- An ex-con returns to Dixon Mills from his prison sentence which he served for the murder of his fiancée's father. She sees that as a tragic accident and still wants him enough to have a home with him at her family farm. He doesn't want her to know he has an inoperable degenerative eye condition, so he tries to convince her he's tired of her.
- A girl suffering from serious internal disease is reluctant to be treated, and the reason is soon apparent to the doctors- her husband has a bizarre obsession with physical perfection, and he lashes out, threatening them and rumormongering among the townsfolk.
- After only a few hours sleep, Locke must help Sellers with a houseful of patients, which include a lot of kids and a sad, lonely, dying old man. The most dramatic moment is when an injured girl, a murder suspect is brought in by Palmer, who threatens the life of Nurse Wynn with a stolen scalpel.