Grandi has performed for six times at the Festivalbar, conquering twice the platform and winning the Radio Awards.
In 2000, she placed second in the Sanremo Music Festival with a song written together with Vasco Rossi.
She performed lead vocals on the song "Blue", the closing track on French producer Hector Zazou's 2003 album Strong Currents.
During her career she has sung in Spanish and has performed duets in German, French, Indian and in African languages, selling around 5 million records and earning 9 top.
Her first album, Irene Grandi, contained songs written with Eros Ramazzotti ("Sposati subito") and Jovanotti ("T.V.B.").
In 2004, she made her debut as television presenter with Marco Maccarini at the Festivalbar.
She has participated five times at the Sanremo Music Festival gaining the podium in 2000.
She debuted in the Sanremo Music Festival in the category New Proposed with "Fuori", in 1994, which was later won by Andrea Bocelli, who was also debuting the same year.
In the 2009 she has won a Wind Music Award, and in 2011 a Sanremo Hit Award.