- 1988 graduate of Limestone High School where he was All-State in baseball and basketball. Played baseball and basketball at Illinois Central College. Was Junior College All-American honorable mention. Served as honorary co-chairman of the United Way Home Run Derby over the last five seasons.
- First Baseman for Cleveland Indians (1991-2002; 2011[end]), Philadelphia Phillies (2003-2005; 2012[start]). Chicago White Sox (2006-2009[start]) Los Angeles Dodgers (2009[end]), Minnesota Twins (2010-2011[start]), and Baltimore Orioles (2012[end]).
- Cleveland Indians All-Time Homerun Leader (334).
- Cleveland Indians All-Time Walks Leader (997).
- Hit 47 home runs to win National League home run title in 2003, his first year with the Philadelphia Phillies. The total was tied for the Major League Lead with Alex Rodriguez of the Texas Rangers.
- In the next-to-last game at Philadelphia's Veterans Stadium, Thome became the last player to hit two home runs in a game at the stadium. His second home run of the game was also the last one ever hit there.
- Milestone home runs: 1 - October 4, 1991, at Yankee Stadium, off Steve Farr; 100 - May 14, 1997, at The Ballpark in Arlington, off Bobby Witt; 200 - April 15, 2000, at Jacobs Field, off Mark Clark; 300 - June 2, 2002, at Hubert H. Humphrey Metrodome, off Eric Milton; 400 - June 14, 2004, at Citizens Bank Park, off Jose Acevedo; 500 - September 15, 2007, at White Sox Stadium, off of Dustin Moseley;.
- Daughter, Lila Grace, born on December 15, 2002.
- Made major league debut on 4 Spetmeber 1991.
- He and his wife welcomed a baby son in mid-November.
- Sister, Kari Thome, engaged to Sam Stevens.
- Son Landon, born 16 November 2007.
- Playing for the Philadelphia Phillies (March 2003)
- (November 23) The Philadelphia Phillies agree to trade Thome to the Chicago White Sox for center fielder Aaron Rowand and two minor league pitchers. (2005)
- Inducted into the Cleveland Indians Hall of Fame in 2016.
- Inducted into the National Baseball Hall of Fame in 2018.
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