The bad guy's name "Pancho Vanilla" is a pun on that of Pancho Villa, a Mexican Revolutionary War general who once raided a U.S. border town, was defeated, and was subsequently a fugitive for a time from the pursuing U.S. Army.
This was the first film produced by DePatie-Freleng Enterprises, a newly-owned independent studio founded by former WB head presidents David H. DePatie and Friz Freleng after the original Warner Bros.'s in-house animated studio closed down in 1963. All of the shorts which was released from 1964 until 1967 featuring Looney Tunes characters such as Daffy Duck and Speedy Gonzales, from most of the shorts produced by DFE until Warner Bros./Seven Arts re-opened its revival in-house animation studio in 1967 where Robert McKimson is returned from the studio in 1968. The final Golden Age Looney Tunes cartoon, Injun Trouble (1969), was released in 1969 when Warner Bros. was bought out by The Kinney National Company (later known as Warner Communications), in 1970.
This is Speedy Gonzales' first appearance in the DePatie-Freleng era.
The only cartoon to co-star Speedy Gonzales and Yosemite Sam (known as Pancho Vanilla) instead of Sylvester.
The title appears to be a pun on that of "Hernando's Hideaway", a popular show tune in the tango style.