Christopher Larkin responded to the critics by saying, "I wanted to say that same-sex relationships are no more problematic but no easier than any other human relationships. They are in many ways the same and in several ways different from heterosexual relationships but in themselves are no less possible or worthwhile". (as quoted The Celluloid Closet pg. 208, 1987).
The film was not financially successful. The writer/director/producer, Christopher Larkin, moved to California in the late 1970s. In 1981, Larkin published a book, "The Divine Androgyne According to Purusha." Larkin committed suicide on June 21, 1988.
Coincidentally, Vito Russo, appears in A Very Natural Thing in a bit part, was the writer of the book, The Celluloid Closet (1995), which was made into an award-winning documentary, of the same name, in 1995, which was seven years and five years, respectively, after the deaths of 'Christopher Larkin (I) and Vito Russo.
Co-screenwriter Joe Coencas is alive and well and living with his husband in Brooklyn.