One of the reasons for Michael J. Fox's refusal to reprise his role in the sequel to Teen Wolf (1985) is that he had no desire to go through the arduous process again of getting into makeup to play the werewolf.
Alyssa Milano was scheduled to do a third film about a teen wolf girl playing football in high school. She was to receive help from her father Scott and uncle Todd. But the poor performance from this film canceled those plans.
James Hampton (Uncle Harold) and Mark Holton (Chubby) were the only actors to reprise their roles from Teen Wolf (1985).