Bruce Campbell cited Brisco County Jr. as his favorite role. On the special DVD featurette he commented "it was the most exhausting, physically demanding year of my life. It was also the best." The other cast members all shared similar sentiments.
Though the show only lasted one season, the series' majestic theme song composed by Randy Edelman found a new life as part of NBC's sports productions, namely during NBC broadcasts of the World Series and the Olympic Games (played while announcing the upcoming events).
Bruce Campbell did a standing back flip during his audition. His reasoning was that because the show would be very action-packed, he wanted to impress the producers with his ability and willingness to handle himself physically.
To signal important or dramatic turns in the plot, and often when Brisco County Jr. is introduced an eagle can be heard screeching in the distance.
The pilot episode Pilot (1993) featured a reporter named Jonah Collier who was played by Dan Gerrity. Collier was originally supposed to be a recurring character who would provide plot explanation at the beginning of episodes while covering news stories. The character was removed because the producers decided that the presence of Socrates Poole and his role as a provider of plot exposition made Jonah Collier unnecessary.