In this show, Tony Shalhoub plays a carefree type personality whereas Neil Patrick Harris plays a germaphobe. After the show was canceled, they both have successful careers playing the opposite roles. Tony as the germaphobe in "Monk" and Neil as the carefree Barney in "How I Met Your Mother".
Jessica Cauffiel appears in several early cast photos that are in circulation. She was replaced by Heather Dubrow prior to the show's premiere.