Leonardo does some training on the roof tops until the Foot Ninjas came to attack him, and little does he know, is that the Shredder is still alive and well.
The Shredder is leaving Earth in a spaceship of his own construction, intent upon wreaking havoc on the Utroms and the galaxy. Splinter, the Turtles and Bishop attempt to bring down his ship before it's too late.
The Turtles and Splinter continue to fight their way up through the Foot Headquarters skyscraper, facing down three misshapen Mutant Shredder Clones, a hallway of traps, and never-before-seen supernatural foes.
It's down and dirty time. Splinter is imprisoned. Leo is dying of poison. Don and Usagi are fighting for their lives and the life of the Daimyo against a horde of assassins.
As the BattleNexus Tournament continues, Leonardo has been poisoned and lies unconscious fighting for his life. Splinter is wrongly imprisoned for an attempt on the Daimyo's life.
The turtles have their hands full fighting the mob, the Purple Dragons and what's left of the Foot. Now, they've joined forces with Karai, who used to be the Shredder's right hand "man." Can they trust her?