David Kaufman voices a character originally played by Michael J. Fox. He previously stood in for Fox in Back to the Future (1991).
With the exceptions of Hugh Laurie, Jeffrey Jones & Marc John Jefferies,none of the actors from the films reprised their roles.
The biological Little children have the same names as the HBO hippos.
Both Kevin Schon and Quinton Flynn replace Nathan Lane as the voice of Snowbell in the series. Both actors had previously replaced Lane as the voice of Timon in the Timon & Pumbaa (1995), while Schon is known to serve as Lane's voice double in other projects.
The TV Series takes place after the events of Stuart Little 2.