According to David Shore, after Hugh Laurie's audition, executive producer Bryan Singer said, "See, this is what I want, an American guy." Singer was unaware of the fact that Hugh Laurie is British.
Hugh Laurie's father was a doctor, and he feels a tinge of guilt at "being paid more to become a fake version of my father."
As a tribute to the London-based detective Sherlock Holmes, House's home address is 221B.
Although other characters occasionally insinuate that Dr. Robert Chase (Jesse Spencer) is a bit dim, he came up with more correct diagnoses than any other supporting character throughout the series.
On Inside the Actors Studio (1994), Hugh Laurie admitted that when he first read the script for this show (which did not have the title of "House M.D." at the time), he believed that the character of Wilson was the lead. He couldn't think that a man such as House could be the star of the show.