| Fiona Apple | ... | Herself (segment "Criminal") |
 | Audioslave | ... | Themselves (segment "Cochise") |
| Beck | ... | Himself (segment "Devil's Haircut) |
| Brian Bell | ... | Himself (segment "El Scorcho") (con il nome Weezer) |
| Chester Bennington | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| David Blaine | ... | Himself (segment "Criminal") |
| Rob Bourdon | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| David Bowie | ... | Himself (segment "Jump, They Say") |
| Peter Buck | ... | Himself (segment "Strange Currencies") (con il nome R.E.M.) |
| Johnny Cash | ... | Himself (segment "Hurt") |
| Chris Cornell | ... | Himself (segment "Cochise") (con il nome Audioslave) |
| Rivers Cuomo | ... | Himself (segment "El Scorcho") (con il nome Weezer) |
| Brad Delson | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| Tom Dumont | ... | Himself (segment "Hella Good") (con il nome No Doubt) |
| Garrett Dutton | ... | Himself (segment "Cold Beverage") (con il nome G. Love) |
| Terry Ellis | ... | Herself (segment "Free Your Mind") (con il nome En Vogue) |
| Mark Everett | ... | Himself (segment "Novocaine for the Soul") (con il nome The Eels) |
| Phoenix Farrell | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| Flea | ... | Himself (segment "Can't Stop") (con il nome Red Hot Chili Peppers) |
| John Frusciante | ... | Himself (segment "Can't Stop") (con il nome Red Hot Chili Peppers) |
| Vincent Gallo | ... | Himself (segment "99 Problems") |
| Kim Gordon | ... | Herself (segment "Little Trouble Girl") (con il nome Sonic Youth) |
| Joseph Hahn | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| Cindy Herron | ... | Herself (segment "Free Your Mind") (con il nome En Vogue) |
| Janet Jackson | ... | Herself (segments "Scream" and "Got Til It's Gone") |
| Michael Jackson | ... | Himself (segment "Scream") |
| Mick Jagger | ... | Himself (segment "God Gave Me Everything") |
| Jay-Z | ... | Himself (segment "99 Problems") |
| Maxine Jones | ... | Herself (segment "Free Your Mind") (con il nome En Vogue) |
| Tony Kanal | ... | Himself (segment "Hella Good") (con il nome No Doubt) |
| Anthony Kiedis | ... | Himself (segment "Can't Stop") (con il nome Red Hot Chili Peppers) |
| Lenny Kravitz | ... | Himself (segment "Are You Gonna Go My Way?") |
| k.d. lang | ... | Herself (segment "Constant Craving") |
| Linkin Park | ... | Themselves (segment "Faint") |
| Madonna | ... | Herself (segments "Rain" and "Bedtime Story") |
| Mike Mills | ... | Himself (segment "Strange Currencies") (con il nome R.E.M.) |
| Tom Morello | ... | Himself (segment "Cochise") (con il nome Audioslave) |
| No Doubt | ... | Themselves (segment "Hella Good") |
| Butch Norton | ... | Se stesso (con il nome Eels) |
| Q-Tip | ... | Himself (segment "Got Til It's Gone") |
| Red Hot Chili Peppers | ... | Themselves (segment "Can't Stop") |
| R.E.M. | ... | Themselves (segment "Strange Currencies") |
| Trent Reznor | ... | Himself (segments "Closer" and "The Perfect Drug") (con il nome Nine Inch Nails) |
| Keith Richards | ... | Himself (segment "Wicked as it Seems") |
| Dawn Robinson | ... | Herself (segment "Free Your Mind") (con il nome En Vogue) |
| Chris Rock | ... | Se stesso |
| Rick Rubin | ... | Himself (segment "99 Problems") |
| Mike Shinoda | ... | Himself (segment "Faint") (con il nome Linkin Park) |
| Chad Smith | ... | Himself (segment "Can't Stop") (con il nome Red Hot Chili Peppers) |
| Shannyn Sossamon | ... | Herself (segment "God Gave Me Everything") |
| Gwen Stefani | ... | Se stessa (filmati di repertorio) |
| Ben Stiller | ... | Himself (segment "Romanekian") |
| Michael Stipe | ... | Himself (segment "Strange Currencies") (con il nome R.E.M.) |
| Robin Williams | ... | Himself (segment "Romanekian") |
| Adrian Young | ... | Himself (segment "Hella Good") (con il nome No Doubt) |
| Sonic Youth | ... | Themselves (segment "Little Trouble Girl") |
