Sigourney Weaver's character was written as a man. It wasn't until late in pre-production that it was decided that the studio executive role could actually be a woman instead. Still, no line was re-written for the gender change, although at one point she politely kisses a male associate at work. Even the name Lenny was kept.
In this movie, Sigourney Weaver plays a television network president. Weaver's father, Sylvester L. Weaver Jr. (aka Pat Weaver), was for many years president of NBC; this movie's writer/director, Jake Kasdan, was a producer and writer on Freaks and Geeks (1999), which aired on NBC (albeit many years after Pat Weaver's retirement).