The nickname "Burford" was a nod to the group of friends Dick and Jerry hung around with in high school that called themselves The Burfords.
Stacey is played by Dick Van Dyke's real-life younger brother, Jerry Van Dyke.
A bit of fourth wall breaking as Stacie says at the end of part one "I don't know if a week's enough time."
Once more Buddy is addressed with the nickname of Mel Brooks, the comedian on whom the character of Buddy is based,"The human joke machine".
The title is based on the expression: "Am I my brother's keeper?" from Genesis 4:9, spoken by Cain when asked where his brother Abel is by God.