One of Morey Amsterdam's catch phrases from his stage act ended up in this show. During his telling a joke, he says, "Funny you should ask...". Amsterdam was also known as "The Human Joke Machine", which also is mentioned here.
Filming of the first episode started on January 20, 1961, the same day that John F. Kennedy was sworn in as President of the United States.
Rose Marie, the actress who plays Sally Rodgers, is in real life a close friend of Jimmy Durante. The impression she does at the party is part of her act in real life.
Mary Tyler Moore is only a little over two years older than the actress who plays the teenage babysitter.
Rose Marie isn't wearing the black bow in her hair because her husband in real life, Bobby Guy, was still alive. She started wearing the black bow in every show only after she became a widow on May 27, 1964.