When Brian and Seabreeze are caught by the police in the sleazy motel, the news photo freeze resembles the famous photo of Elian Gonzales being removed from his relatives' home in Florida.
During the court scene it's learned that Meg's real father is named Stan Thompson.
When Peter shows Brian what he is going to look like after he gets neutered he is shown eating chocolate, in real life chocolate can be poisonous to dogs so Brian would have died.
Carter mentions that one of his poker buddies is going to bring over his Stretch Armstrong. Stretch Armstrong is a real toy manufactured by Cap Toys, and is, as the name implies, a rubber man that can be stretched.
Music from this episode is featured on the CD soundtrack album "Family Guy - Movement 1".