Kif and Amy meet for the first time in this episode, beginning the romance between them. The relationship was originally meant to be a one-off joke; however, the writers found it to be convenient and used it in later episodes.
The title of this episode is a reference to Walter Lord's book "A Night to Remember", a non-fiction account of the sinking of the RMS Titanic in 1912.
The bartender, iZac, is a parody of the character Isaac (played by Ted Lange) from The Love Boat (1977), while his name is a reference to iMac computers.
This is the first time we learn of Hermes' history as a professional Limbo champion.
This is the first time that Leela and Fry are seen in a romantic situation