At the beginning of the series, a woman has the name of Rebecca Adler. The female antagonist in the Sherlock Holmes is named Irene Adler. House is based on Holmes.
Only the pilot was filmed with an orange hue lens.
House develops an addiction to the pain medication Vicodin and reveals that his limp resulted from an infarction.
Although this episode gave David Shore his first nomination for a Humanitas Prize, this honor was awarded to the writer of an episode of The West Wing. However, Shore won the Humanitas the following year for another episode, Three Stories, in Season 1.
At several key moments, immediately after Wilson persuades House to take on the first patient, the score contains the iconic first four notes of the original Star Trek title theme. However, later episodes have different scores, and this early leitmotif never returns.