At the end of the episode, inserted between the fading producer credits and the end credits, Tom Welling and Christopher Reeve appear in a public service announcement for the 'Christopher and Dana Reeve Foundation'. The segment is also present on the DVD release, but unfortunately sometimes omitted during syndication. Sadly for the viewers since it shows Reeve in a good spirited mood, smiling, and even adding a final ad-libbed punch-line not present on the scripted cue cards, causing the entire crew behind the camera to burst out into a loud laughter. The segment is repeated in the season 3 episode 'Legacy', in which Reeve made his second and last appearance on the show, and final acting appearance altogether, before his death.
The musical score for Dr. Virgil Swann is "The Fortress of Solitude" and "Main Theme" from Superman (1978), originally composed by John Williams.
"Rosetta" and "Legacy" marked Christopher Reeve's final film appearance before his death. Music from the original Superman (1978) film can be heard during his scenes.
This is the first time where Clark gets to know the names pertaining to his origin. Krypton, his birth place and his real name Kal-El.
As Christopher Reeve was paralyzed, all his scenes were filmed in New York City where he lived. The production team were totally surprised by Reeve's stamina, shooting for 12 hours straight, then doing a press conference and finally a public service announcement.