A scientist is talking about the Fleischer comet, named for Max Fleischer who was responsible for the Superman 1940s animated film series.
Al Roker, who plays the weatherman, was a nationally known weatherman at the time.
When Kara meets Clark Kent at the daily planet, she's wearing a brown hair wig and glasses. This goes back to the disguises Supergirl used to wear to hide her secret identity in the comics and other media. Sometimes she would wear a wig, other times just glasses and still other times where she would wear both.
This episodes features the voice talent of Scott Menville, who would go on to voice the DC character Robin in Teen Titans and affiliated works.
The casting of Edward Asner as Granny Goodness was inspired by Boris Karloff's guest appearance as Mother Muffin in "The Mother Muffin Affair (1966)".