Isaiah Burke and wife Rosemary are abolitionists trying to lead a group to freedom but slave catchers are close behind. Hickok helps them out but also falls in love with Mrs. Burke. Isaiah is captured and must be rescued by the riders.
After visiting his sister in Kansas, Hickok meets the attractive young wife of a militant abolishionist. He reluctantly gets involved, and while saving the woman's life, ten others lose theirs. The abolishionist is wanted by the law. In Kansas City, Kid sees a wanted poster on Isiah Burke.