Scott Halberstadt (Eric) actually hit Drake Bell while filming the punch scene, resulting in a bloody nose.
The squeak toy featured in this episode is Rolie Polie Olie.
This episode takes place right after Josh Is Done; so, when Josh, Craig and Eric finish their Organic Chemistry test, the new introduced chemistry test books could have taken place on the day after that episode. Drake spitting mouthwash into Clayton's water bottle could've been his revenge for the incident that Clayton witnessed that day.
In Nick Asia, during the fight between Josh and Mindy, the camera goes to Drake singing with Craig and Eric, leaving out the part where Josh and Mindy kiss.
Craig says "rat's hat" then Drake repeats it, confused. In The Amanda Show, Drake played a character named Tony Pajamas, who often said "rat's hat."