The team is initially attempting to diagnose one patient, which ends up becoming two patients presenting with the same symptoms, and this is the second time the team has two patients instead of just one.
One of the robbers says, "Time to make the doughnuts..." this is a line is from a famous old Dunkin' Donuts commercial in which a tired employee gets up at 2 a.m. to go into work and mutters the line to himself groggily.
This episode starts a story arc that runs two seasons.
Jurnee Smollett plays a dying patient in Grey's Anatomy whose boyfriend is also named Jeremy and who is also dying.