No. This is the second Kevin Smith film that does not feature Jay and Silent Bob, the first being Jersey Girl. Smith has said he is taking a break from the View Askewniverse, but may return to it someday.
There are two songs during the Zack and Miri sex scene. The first is called "My Assistant Will Take Notes" by Forbidden Ensemble, this plays in the background as their scene begins. The second song is called "Hold Me Up" by Live and it plays as Zack and Miri fall onto the pile of coffee beans and have sex.