Morjana Alaoui, actress that played Anna, broke three bones during the movie shoot and had to stay in bed for six weeks.
Mylène Jampanoï and Morjana Alaoui, actresses that played Lucie and Anna, both stated in an interview that they would never work with the director Pascal Laugier again.
Pascal Laugier has confessed that he wrote the screenplay for the film in a state of clinical depression, bordering on suicidal thoughts, which is why the film is said to have a nihilistic and depressing subject matter.
In Pascal Laugier's previous film Saint Ange (2004), the main character is called Anna Jurin. In Martyrs, Anna is one of the female leads' character names, whilst Lucie Jurin is the other.