As House is in the bathroom, his bathroom stall has writing that says, "James Wilson is adorable."
The song playing in the scene near the middle is a José González cover of "Teardrop" by Massive Attack. "Teardrop" is the House M.D. theme song (in the US).
Tied with the previous episode, House's Head (2008), it is the highest rated episode of the series.
Amber took amantadine, which was previously used to prevent or treat influenza A; however, multiple studies proved it to be ineffective, so the US Centers for Disease Control and Prevention no longer recommends it for the flu.
One of Amber's lines is, "Well, you can't always get what you want," referring back to the first and last episodes of season one, in which the song You Can't Always Get What You Want by The Rolling Stones was mentioned and played. This song also plays in the first episode of the season three.