Near episode's end, Clark confides in Lois his fears of never finding his soul mate. Ironically, in season five's "Fade (2006)", Lois confided in Martha her own fears of never finding the right guy.
Maxima is Smallville's version of the DC Comics character of the same name. As in this episode, the comics version of the character plans to mate with Superman or Clark in Smallville.
This is the second time that Lois has walked in on Clark making out with another woman. The first occurred in "Hypnotic". Lois is noticeably more hostile in this episode.
The spinning dual-ring frame holding the Crystal of Knowledge is the same design used to hold the imprisoned Zod, Ursa, and Non in Superman: The Movie and Superman II.
Chloe says to Jimmy Olsen that she was 15 years old at the time she wrote her love letter to Clark. "Fever" originally aired on February 18, 2003 and, assuming that the in-show time matches the time in the real world, that would make her birth year 1988 or 1987, depending on the precise part of the year she was born, although that has always been disputed.