The series takes its name from the Rubicon (Latin: Rubico; Italian: Rubicone; Romagnol: Rubicôn), the ancient river Rubicon in northeastern Italy, famously crossed by Julius Caesar in 49 BC, which is the origin of the phrase "crossing the Rubicon," an idiom that means that one is passing a point of no return.
One of the posters on the wall in Miles' office is of The Invisibles, a comic book which dealt with secret organizations and conspiracies.