This is one of those riveting documentaries that comes along once in a while. The cinematography is beautiful. Using many motion shots over landscapes and forests and computer animation, a useful overview of the conquest of the Americas and the Columbian Exchange is given. Many of the ideas are strongly reminiscent of Jarrod Diamond's book Guns, Germs and Steel.
Contrary to the sentiments expressed in the inexplicable and unjustified rant by SanFernandoCurt in his review here, the language is relatively neutral and non-political -- it tells it like it is. There were many things -- good and bad -- that resulted from the Columbian Exchange. There is no hint of "Marxism" or spin in this documentary.
There is mention of biological imperialism once in the second episode. I'll admit that the 100 million population estimate is at the high end of the range -- Europe only had 60 million in 1492. But why not? As the documentary states the Americas are a fertile land that was managed by the natives and is 10 times the size of Europe. Diseases like smallpox and influenza probably wiped out 90%+ of the native American population.