Frederick tells Lenore that she should give the name "Grampus" to the ship they are making in the bottle. Grampus is the name of the ship in Poe's novel, "The Narrative of Arthur Gordon Pym".
Camille (Kate Siegel) says that they used to call the test facility the Rue Morgue. This is a reference to another Edgar Allan Poe story, "Murders in the Rue Morgue".
A character says "Toby, damn it" during this episode. "Toby Dammit" was the name of Terence Stamp's character in the Fellini section of Spirits of the Dead (1968), also written by Poe.
Each episode references a title or famous line from Edgar Allan Poe. This episode is named for the short story "The Masque of the Red Death," first published in 1842.
During the rave, Jenny is wearing the same mask worn by the home invader in Hush (2016) which was written/directed by Mike Flanagan and starred his wife Kate Siegel, who plays Camille.