This episode shows a rare example of a point-of-view shot of a droid character. When R2-D2 is tangling with the gundarks, one shot is directly from his P.O.V. with his manipulators extended. Later, when he spots the bounty hunter speeder bikes approaching, we see that Artoo's vision mimics the view of a macrobinocular.
During the Jedi Temple briefing, Plo Koon makes mention of the Hydian Way, which is a hyperspace trade route first established in the Expanded Universe.
The title "R2 Come Home" refers to the film Lassie Come Home (1943). A special trait of the popular collie was that she was able to understand her human counterparts who give orders especially in times when they were in distress. Like Lassie, Artoo saw his master was in distress and returned to Coruscant to get help for Anakin Skywalker and Mace Windu who had succumbed to a trap set by Boba Fett.
The speeder bikes that the bounty hunters use have Aurebesh lettering on the saddle that reads "LET'S GO ALREADY."
The 'Jedi fortune cookie' message that opens the show reads "Adversity is friendship's truest test."