This is the second time that Serinda Swan has appeared in Supernatural. The first time was season 1 episode 21, Salvation (2006), when she played a hospital receptionist.
Fiona Vroom has a small role as the dental assistant in this episode. She previously appeared in Two Minutes to Midnight (2010) as "nurse".
When the bartender said that she had been "snorting oxy all day" she was referring to the opioid analgesic Oxycontin (oxycodone).