Sheldon describes Patrick Star from SpongeBob Squarepants as wearing boxer shorts when Patrick actually wears swim trunks.
During Sheldon's "Flash running to the Grand Canyon" fantasy, he's shown crossing the Colorado Street Bridge to get to the Grand Canyon. Sheldon and Leonard's apartment is on Los Robles Avenue, Pasadena; the Grand Canyon is in Arizona, east of Pasadena; the Colorado Street Bridge is west of Los Robles Avenue; Sheldon-Flash would be running away from the Canyon to get to the bridge.
The place which is shown as the Grand Canyon is in reality the 'Dead Horse Point' near Moab in Utah.