Another reference to Sherlock Holmes is made when the patient asks House how many high-functioning heroin users he knows.
Amber Tamblyn's husband, David Cross, auditioned for the role of House.
Taub makes the comment, "Things would have been just been fine without Pippi Longdivision," referring to Masters' intelligence. In real life, Amber Tamblyn kicked off her career at age ten when an agent spotted her in a performance of Pippi Longstocking.
Taub says, "Hate to steal the spotlight from Small Wonder over here," referring to the 1985-89 syndicated TV series Small Wonder (1985) about an engineer who builds an android child, VICI (AKA Vicki), and brings her home to meet the family.
This episode is Amber Tamblyn's first appearance as Martha M. Masters, a brilliant third-year medical student joining House's team.