This episode didn't contain opening credits.
House wears a lab coat for the fifth time.
House says, "Pop quiz, hotshots," referring to the 1994 action movie "Speed," starring Keanu Reeves, Dennis Hopper, and Sandra Bullock, in which that phrase is used during a number of key confrontations.
Taub's wife mentions that her brother broke Taub's nose five years ago when he discovered that Taub had been cheating, but Taub comes clean about his infidelity after he had started working for House, less than five years before.
House uses mute expressions to communicate his assessment of a differential diagnosis session's direction. The expressions are very similar to Rowan Atkinson's in and as Mr. Bean. Hugh Laurie who plays House starred in the Black Adder series on BBC with Rowan Atkinson in the titular role. Since he is now executive producer of the House Series, this may be Hugh tipping his hat towards an old friend.