- Rodrigo Borgia: [to Lucrezia] Do not dare to lecture me on diplomacy, little girl. Or seek to confuse me with manipulation. I am the master of both.
- Giulia Farnese: If you do not find yourself up to the tasks, then by morning you will find yourself in the cargo hold of a ship bound for Tierra del Fuego.
- Maria Enriques de Luna: Lady, I will do as you command.
- Giulia Farnese: Good. Now, um, have you ever heard of arsenic. Smells like almonds.
- Giovanni de Medici: You're a Cardinal, not a soldier. Remember, we fight in the name of our Lord. Faith is a powerful...
- Cesare Borgia: Faith? What good is faith if we are massacred? Faith is a benefit bequeathed to the conqueror.
- Lucrezia Borgia: How you enjoy playing games with our lives. Your heart may care about Cesare, but your soul is dead.
- Rodrigo Borgia: [slaps her face] My soul is Rome, and we will make any sacrifice, even our daughter, to save this city!