Colin Ferguson (Sheriff Jack Carter) stated that they had "no prep time" for this episode and started filming this at 11am directly after wrapping the previous episode (Friendly Fire (2012)). All impressions were done "after working with people for six years". Fargo was the easiest and Zane was the hardest to do.
After Café Diem was rebuilt, the restroom doors are no longer named "Ladies" and "Gentlemen". They now read XX and XY for the female and male chromosomes.
The pair of teleport pads Dr. Fowler is using for his experiment look very similar, if not identical, to the portable multi-universe-membrane-crossing pad previously seen in "Insane in the P-Brane", when Jack and Tess meet for the first time.
When Warren receives the Therapy from his ICD, there is only mild pop and no body reflex. In actuality the pop can wake someone over a hundred feet away behind a closed door, with the consumer of the Therapy writhing and screaming in pain if only for a second because it is the equivalent of having your fingers in seven different wall outlets at the same time.