Although it's never mentioned in the series, in the comics, Skaar is actually the biological son of Hulk. It remains unclear why this story element was never introduced in this show.
Several characters make reference to having seen Marvel Cinematic Universe films such as The Avengers (2012) and Guardians of the Galaxy (2014), making the MCU a fictional part of this version of the Marvel Universe (Earth-12041).
This show features two cast members that had appeared in Buffy the Vampire Slayer (1997), Seth Green and Eliza Dushku.
The voice of Red Hulk, Clancy Brown, is also the voice of Mr. Krabs on SpongeBob SquarePants, another red-skinned ex-military man. The voice of SpongeBob, Tom Kenny, has a cameo in this show in the episode "Mission Impossible Man", as the eponymous Impossible Man.
This animated series takes place in the Earth-12041 version of the Marvel Comics multiverse, together with Ultimate Spider-Man (2012), Hulk: Where Monsters Dwell (2016) and the first four seasons of Avengers Assemble (2012).