This is the first Resident Evil game in the franchise where Alyson Court does not provide the voice for Claire Redfield. She was replaced by "James Baker" (an alias for Ali Hillis). Court has stated she wasn't contacted by Capcom about reprising the character or even informed about her replacement, and that she would have loved to return to voice Claire stating the character had become a part of her over the many years.
As the English voice recording was not done with a SAG-AFTRA approved contract, most of the American voice actors were using pseudonyms or at least similar versions of their names in order to distance themselves from their union-approved work.
This is the second game in the series to use the Uroboros virus as a plot element (first being Resident Evil 5 (2009)). However, this is the first game to analyze the effects of a successful merging, as well as using it to make B.O.W.s.
At the time, the game set a new standard for use of profanity in the series. Most of the other installments had an M rating for mild language, but usually nothing worse than use of a few s-words. Resident Evil 5 (2009) and Resident Evil 6 (2012) were moderate for incidental uses of the f-word and other crude expletives. Resident Evil Revelations 2 features copious use of f-bombs, a lot of them used by a 20-year-old.