The two actors who portray Eric & Lisa Parker were real-life spouses Rebecca Luker and Danny Burstein. Luker passed away in 2020.
The graphic novel seen on Avery's desk when she wakes up in the intro scene is Stitches by David Small. The book, released in the early 2000's, is a memoir about the author's life, which involved him dressing as a girl in childhood and being bullied by his peers, in 1950's America.
Danny Burstein (Eric Parker) previously played the role of Mr. Brookfield in episode 2.2, Honor (2000).