There's an 11 year difference between Carrie Preston and Ethan Embry who played biological mother to Ethan's coyote.
Lily Tomlin (Frankie) and Sam Elliott (Phil) also worked together on Grandma (2015) as Elle & Karl respectively.
June Diane Raphael (Brianna Hanson) & Sam Elliott (Phil) also worked together on episode 6.4, Doppelgängers (2013), of Parks and Recreation (2009) as Tynnyfer & Ron Dunn respectively.
John Getz has starred alongside Martin Sheen's sons Charlie Sheen and Emilio Estevez in Men At Work.
Martin Sheen (Robert Hanson) & Sam Elliott (Phil) also worked together on Gettysburg (1993) as Gen. Robert E. Lee & Brig. Gen. John Buford respectively.