Musically, "Two of Hearts" is a Hi-NRG song.
The track utilizes vocal sampling with the repetitive usage of the line "I Need You" in its hook.
The lyrics of the song revolve around love and romance.
It entered the US Billboard Hot 100 chart in mid-July 1986, breaking into the Top 40 in mid-August, and peaking at number three during the autumn of that same year to become one of the highest-selling singles of 1986.
The music video was directed by Peter Lippman.