During the engagement party scene, Jed Milgrim serenades His fiancé, Adelaide, with a rendition of "Every Breath You Take" by Sting. Jed and Owen's mother is played by Trudie Styler, who is married to Sting.
At around the 27minute mark, a disk can be seen on the desk of Dr. James K. Mantleray's (played by Justin Theroux) entitled 'Beasts of Urination'. This is a pun on 'Beasts of No Nation' (2015) written/directed by Cary Joji Fukunaga who also created/directed 'Maniac' (2018).
The Japanese text on a rainbow-colored dime bag in Dr. Muramoto's deskdrawer reads "Aphrodite".
The film showed in this episode is "To Catch a Thief."
This episode is the first time Owen is offered a drink called a "Gimlet".