While it is likely that arachnid book lungs would not provide sufficient oxygen to maintain life in a spider the size of the 'mother', it is equally likely that spiders as massive as her brood would not be able to walk on ceilings.
Dr. Meredith refers to a poisonous spider - the correct term is venomous, an expert would never make that mistake.
At the start, Jade McIntyre refers to her friend as 'Ah-na'. However, after that instance, it's always pronounced 'An-na'.