At one point Dr. Emma Fischer references a movie she once saw where the astronauts blew themselves out of an airlock. She is referencing the movie "Sunshine"
During the course of game, various flags are seen, representing the various factions that had a hand in space station Observation's construction and management. One of the flags visible is a Welsh flag, which is clearly a nod to Kezia Burrows, who is Welsh and provided the voice and motion capture for the man character, Dr. Emma Foster.
Lead voice actors Kezia Burrows (Dr Fisher) and Anthony Howell (SAM) also voiced the lead characters in Alien: Isolation (2014), where they again played a space-bound survivor and an artificial intelligence respectively.