Secretly furloughed from prison due to failing health, Lex Luthor visits his sister Lena to seek her help finding a cure. Savvy as ever, Lena is suspicious of Lex's motives, but when she's faced with a life and death situation, she must decide how she truly feels about her brother. Meanwhile, Supergirl and J'onn face off against Manchester Black. James' sister Kelly comes to town.
—Derek Simon & Nicki Holcomb