The director's reason for making the film? "I have a 12-and-a-half-year-old daughter who's beautiful, and I'm sure she's going to come home one day with some Lithuanian, Samoan, punk-rock drummer dude, and I thought if I did this movie I'd be able to work out my issues before that day comes."
At an estimated cost of $100,000, digital effects were used to remove Ashton Kutcher's red Kabbalah bracelet in every scene in which he appeared.
Ashton Kutcher suggested that his character be Jewish, to add another dimension to his conflict with the Christian Percy Jones. The idea was scrapped because the filmmakers wanted to focus on the issue of interracial romance rather than also looking into the interfaith issue.
The Writer's Guild of America (WGA) mandated that William Rose be credited for his work on the original Guess Who's Coming to Dinner (1967). However, he is never actually mentioned in this movie.
As evidenced by the clappers in the deleted scenes section, the working title for the movie was "The Dinner Party".